How long does it take for Trelagliptin to be effective in treating diabetes?

Trelagliptin (Trelagliptin), as a DPP-4 inhibitor, mainly inhibits the DPP-4 enzyme and prolongs the action time of gastrointestinal hormones such as GLP-1, thereby promoting the secretion of insulin and inhibiting the secretion of glucagon to control blood sugar. Clinically, trotagliptin is used to treat patients with type 2 diabetes, usually as a monotherapy or in combination with other antidiabetic drugs.

The therapeutic effects of trolagliptin usually appear gradually within 1-2 weeks after starting the medication. Compared with other antidiabetic drugs, trotagliptin has a milder effect on blood sugar control. Patients usually notice a decrease in postprandial blood sugar levels within a few days after taking the drug, while fasting blood sugar control takes a little longer, and significant effects are generally achieved in about 4 weeks.

For most patients, the effects of trolagliptin usually stabilize after 2-3 months of treatment. At this time, the patient's blood sugar control is relatively stable, HbA1c level (glycated hemoglobin) will gradually decrease, and blood sugar fluctuations will decrease. Long-term use of troagliptin can not only help control blood sugar, but also improve insulin sensitivity in diabetic patients and reduce postprandial and fasting blood sugar levels.

The time and degree of efficacy are also affected by multiple factors. The severity of the patient's condition, complications, diet and exercise, etc. may affect the effectiveness of the drug. For patients with diabetes who are more difficult to control, they may need to be combined with other drugs (such as metformin, GLP-1 receptor agonists, etc.) to enhance the hypoglycemic effect. In addition, individual differences among patients, such as age, weight, basal blood sugar level, liver and kidney function, etc., will also affect the speed of efficacy.

In general, the efficacy of trolagliptin for diabetes generally begins to appear within 1-2 weeks and relatively stable blood sugar control can be achieved within 2-3 months. Patients should carry out long-term treatment according to the doctor's recommendations, and pay attention to reasonable diet, exercise and regular review to achieve the best treatment effect.

Reference materials:https://synapse.patsnap.com/article/what-is-trelagliptin-succinate-used-for