What is the drug encyclopedia information about Bedaquiline/Snaery and how to check it?

Bedaquiline is a drug used to treat multidrug-resistant tuberculosis (MDR-TB) and rifampicin-resistant tuberculosis. It is a diarylquinoline antimycobacterial drug that has a strong inhibitory effect on Mycobacterium tuberculosis and is particularly suitable for tuberculosis patients who have failed traditional treatments. The mechanism of action of bedaquiline is different from other anti-tuberculosis drugs. It mainly inhibits the ATP synthesis of Mycobacterium tuberculosis, thereby reducing the energy supply of the bacteria and inhibiting its reproduction.

Bedaquiline is usually used as part of a combination therapy rather than alone. It is a treatment option only if there are no effective alternative treatments. This is because bedaquiline has certain side effects, such as QTc interval prolongation, liver toxicity, etc., so care must be taken when using it. During treatment, patients need regular ECG monitoring, especially if other drugs that may cause QTc prolongation are co-administered. In addition, liver function monitoring is also very important to ensure the safe use of the drug.

The main indications of bedaquiline are the treatment of multi-drug-resistant tuberculosis (MDR-TB) and rifampicin-resistant tuberculosis. It is suitable for patients 2 years old and above and weighing more than 8 kilograms. In the treatment of multidrug-resistant tuberculosis, bedaquiline is effective against Mycobacterium tuberculosis, especially when patients are resistant to traditional anti-tuberculosis drugs such as isoniazid and rifampicin. Bedaquiline is often used in combination with other anti-tuberculosis drugs as part of a treatment regimen to improve treatment effectiveness and reduce the development of drug resistance.

When using bedaquiline, patients need to follow the doctor's instructions and take the drug strictly according to the dosage and time. Since this drug may cause certain side effects, including QTc prolongation, liver function damage, etc., patients should undergo regular electrocardiogram and liver function monitoring. During use, if serious side effects are found, stop taking the medicine immediately and consult a doctor.

Reference materials:https://www.tballiance.org/compound/portfolio-compound-bedaquiline/