Should Letermovir (Premin) be taken before or after meals and the best time to take it?

Letermovir is an antiviral drug used to prevent cytomegalovirus (CMV) infection in hematopoietic stem cell transplant patients. Its oral absorption and efficacy are limited by administration time and diet. Clinical studies and drug instructions show that letermovir can be taken with meals or on an empty stomach and will not significantly affect the blood concentration and antiviral effect of the drug. Therefore, patients can choose to take it before or after meals according to their own habits to ensure medication compliance.

Normally, doctors recommend that patients take medication at a fixed time every day to maintain a stable drug concentration in the body, thereby maximizing the effect of preventing CMV infection. For patients who eat regularly in the morning and evening, they can choose to take it after or before a fixed meal, but avoid changing the time at will every day. Taking medication at a fixed time can help form a routine and increase the likelihood that patients will follow their doctor's instructions.

If patients are taking other drugs at the same time, especially drugs that are metabolized by the liver, they should inform their doctor or pharmacist to avoid potential drug interactions that may affect the absorption or metabolism of letermovir. In special cases, such as gastrointestinal discomfort or vomiting, doctors may adjust the administration method or dosage according to the patient's condition to ensure the drug's efficacy.

In general, letermovir can be taken before or after meals. The key is to maintain a fixed time and regularity every day. Patients should strictly follow the doctor's medication regimen and dosage regulations, and combine it with their daily habits to form a stable medication regimen to achieve the best prevention of CMV infection, and follow up regularly to monitor efficacy and safety.

Reference materials:https://www.drugs.com/mtm/letermovir-oral-injection.html