Omarigliptin usage, dosage and medication precautions explained

Omarigliptin (Omarigliptin) is an oral long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor, mainly used for the treatment of22 span> type diabetes effectively controls blood sugar by prolonging the action time of insulin-secreting hormones (GLP-1 and GIP), promoting postprandial insulin secretion and inhibiting glucose production.该药的特点是长效作用，一般每周只需服用一次，便于患者长期维持血糖控制，提高用药依从性。

In terms of usage and dosage, it is usually recommended that adults take Ologliptin orally once a week, with each dose of 25 mg. It can be taken at a fixed time every day, without taking the medicine before or after meals. For patients with mild to moderate impairment of renal function, there is usually no need to adjust the dosage. However, in patients with severe renal insufficiency or end-stage renal disease, the safety of the medication should be evaluated under the guidance of a physician, and adjustments should be made as appropriate based on blood sugar control.老年患者和合并基础疾病的患者亦需在医生监测下使用，以确保疗效与安全。

用药注意事项方面，奥格列汀在使用过程中应注意低血糖风险，尤其是与磺酰脲类或胰岛素联合使用时。患者在服药期间应定期监测血糖，避免出现血糖过低或过高的情况。同时，若出现严重肝肾功能异常、胰腺炎史或对药物成分过敏者，应避免使用或在医生严格指导下使用。患者在用药期间应注意观察不良反应，如头痛、胃肠不适或皮疹，并及时向医生报告。

此外，奥格列汀的长期治疗效果与生活方式管理密切相关。患者在服药期间应保持合理饮食、适度运动并定期监测血糖，以配合药物发挥最佳疗效。由于药物为口服片剂，需整片吞服，不可随意掰开或碾碎，以免影响吸收。总之，规范用药、遵循医嘱和结合日常血糖管理，是确保奥格列汀安全有效发挥作用的关键。

Reference materials:https://go.drugbank.com/drugs/DB11992