Summary of contraindications and precautions for taking Lemborexant

Lemborexant, as an orexin antagonist, has significant effects in the treatment of insomnia, but it also requires special attention to some contraindications and precautions when using it. First, leborexan is contraindicated in patients with narcolepsy. Narcolepsy is a neurological disorder caused by an abnormal circadian rhythm. Patients often present with extreme daytime sleepiness and sudden sleep attacks. Since leborexan's mechanism of action is mainly to regulate the sleep-wake cycle by inhibiting orexin receptors, the use of leborexan may aggravate daytime sleepiness in patients with narcolepsy.

In terms of other contraindications, leborexan is not suitable for patients who have allergic reactions or are allergic to the components of the drug. Patients must report any history of drug allergy to their doctor before starting Lebrasin to avoid allergic reactions such as rash, difficulty breathing, facial swelling and other serious symptoms.

In addition, leborexan should be used with caution in patients with hepatic impairment. Since the metabolism of drugs is mainly carried out by the liver, when used in patients with hepatic insufficiency, it may be necessary to adjust the dose or increase the frequency of monitoring to avoid accumulation of the drug in the body leading to toxic reactions. Patients with liver disease must do so under the guidance of a doctor when using leborexan.

During treatment with leborexan, patients should also avoid taking other central nervous system depressants such as alcohol, benzodiazepines, and narcotic drugs at the same time. These drugs may potentiate the sedative effects of leborexan, resulting in excessive sedation and risk of adverse effects.

In addition, because leborexan may cause some patients to experience mild drowsiness or dizziness the next morning, you should avoid driving or operating heavy machinery while using this drug, especially early in treatment, until the patient has a better understanding of the drug's response.

Reference materials:https://medlineplus.gov/druginfo/meds/a620039.html