Datopotamab medication contraindications and cautions

Although Datopotamab (Datopotamab) provides new hope for the treatment of various cancers (breast cancer, non-small cell lung cancer), like all drugs, caution is required during use. The use of this drug may carry unnecessary risks, especially in certain contraindicated groups. For different types of patients, the instructions of medical professionals must be strictly followed when using dabrotuzumab.

The contraindications for dabrotomab mainly include patients who are allergic to the drug ingredients. Any patient who is allergic to dabrotuzumab's active ingredients or excipients should avoid using this drug. Allergic reactions may manifest as severe reactions such as rash, difficulty breathing, facial swelling, etc. Patients need to inform their doctor of their allergic history before use. If the patient experiences an allergic reaction, the drug must be discontinued immediately and emergency treatment must be given.

In addition, dabrotuzumab should be used with caution in patients with severely impaired liver function. Drug metabolism mainly depends on the liver, so patients with hepatic insufficiency may increase the blood concentration of the drug, leading to increased drug toxicity. Such patients need to closely monitor liver function when taking dedabrotuzumab, and adjust the dose or discontinue the drug based on the specific conditions of liver function.

Dedabrotuzumab should be used with special caution in pregnant and lactating women. Although current clinical studies have not clearly shown specific effects on the fetus, pregnant and breastfeeding women should avoid the use of dabrotomab due to the potential risks of anticancer drugs. Especially for pregnant women, the drug may affect the fetus through the placenta, so effective contraception should be used during treatment.

In addition, dabrotuzumab should be used with caution in patients with renal insufficiency. Although the drug is not directly excreted through the kidneys, patients with renal insufficiency may affect the metabolism and clearance of the drug and increase the accumulation of the drug in the body, thus increasing the risk of adverse drug reactions.

Reference materials:https://go.drugbank.com/drugs/DB16410