How many boxes of Talazoparib do you usually need to take in a month?

Talazoparib is an oral PARP inhibitor, mainly used for patients with advanced breast cancer who carry BRCA gene mutations. According to the drug package insert and clinical medication guide, the usual dosage of talazoparib is 1 mg orally once daily. Since the drug is taken daily, patients usually need to prepare a box of 30 pills per month to ensure continuous and stable medication. Continuous use is crucial to maintaining blood concentration and efficacy. Patients should strictly follow the doctor's instructions and are not allowed to increase or decrease the dose or take medication intermittently.

In the domestic market, talazoparib is already on the market and patients can purchase it through local hospital pharmacies. Pharmacies usually provide 1mg*30 capsules, which is convenient for patients to take medication on a monthly basis. At the same time, doctors will evaluate whether it is necessary to adjust the dose or extend the medication interval based on the patient's liver and kidney function, blood profile, and tolerance to ensure the safety and effectiveness of the treatment. Patients should maintain communication with the attending doctor when taking medicine, and regularly review blood routine and liver and kidney function indicators.

The price of talazoparib original drug in overseas markets varies greatly. The specifications of the Hong Kong version and the European version are 0.25mg30 capsules and 1mg30 There are two types of tablets. Among them, the latest price of 0.25mg specification is about 10,000 to 20,000 yuan, while the price of 1mg specification is more than 50,000 yuan. Due to the high price, some patients may obtain drugs through medical institutions or cross-border drug purchase channels, but they need to abide by local laws and regulations, ensure that the sources of drugs are regular, and avoid buying fake or inferior drugs.

In addition, a Laotian generic version of talazoparib has appeared overseas, with a specification of 1mg*30 tablets, and the price per box is about 4,000 yuan (which may change due to exchange rates and market fluctuations). The ingredients of this generic drug are basically the same as those of the original drug, but the suitability and dosage regimen still need to be evaluated under the guidance of a doctor before use. In general, talazoparib patients usually need one box of medicine every month. Whether it is the domestic original medicine or the overseas version, they should be purchased through formal channels to ensure the quality and therapeutic effect of the medicine.

Reference materials:https://pubmed.ncbi.nlm.nih.gov/39520722/