Precautions for use of Tilpotide/Tisiparatide (Mufenda) in patients with abnormal liver function

Tirzepatide is a new dual-target GLP-1/GIP receptor agonist, mainly used to treat type 2 diabetes and obesity-related diseases. Although the drug has a good safety profile in most patients, patients with abnormal liver function require special caution when using it. Since the liver is an important organ for drug metabolism, impaired liver function may affect drug clearance, leading to an increase in blood drug concentration, thereby increasing the risk of adverse reactions. Therefore, it should be used with caution in patients with abnormal liver function.

First, for patients with mild to moderate hepatic impairment, there is usually no need to adjust the initial dose, but treatment monitoring should be strengthened. Doctors may recommend that patients regularly check liver function indicators, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin levels in the early stages of medication, in order to detect abnormal changes early. If there is a significant increase in liver function indicators, it should be evaluated whether to continue taking the drug or adjust the dose.

Secondly, for patients with severe hepatic impairment, current clinical data are limited, so routine use is not recommended. If it is really necessary to use it, it should be done under the guidance of a professional doctor, and liver function and clinical symptoms, such as jaundice, fatigue, nausea or right upper quadrant discomfort, should be closely monitored. Once serious adverse reactions occur, the drug should be stopped immediately and supportive treatment should be given. At the same time, concomitant use with other drugs that may aggravate liver damage should be avoided to reduce the risk.

In addition, patients with abnormal liver function also need to pay attention to lifestyle and dietary management while taking tilsiparatide. Properly controlling the diet structure and avoiding excessive intake of high-fat and high-sugar foods can reduce the metabolic burden on the liver. At the same time, combined with moderate exercise, it can help control blood sugar and weight and reduce the potential impact of drugs on the liver. In short, patients with abnormal liver function need to carefully follow the doctor's instructions, conduct regular reviews, and combine with daily care when using tilsiparatide to ensure the safety and efficacy of the drug.

Reference:https://en.wikipedia.org/wiki/Tirzepatide