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Fostamatinib (Fostamatinib), as a targeted drug for the treatment of chronic immune thrombocytopenia (ITP), has provided an effective treatment option for many ITP patients. However, the use of fostatinib still requires patients and physicians to pay close attention to some key precautions during treatment to ensure the safety and effectiveness of the treatment.

First of all, fostatinib, as aSyk enzyme inhibitor, has a certain inhibitory effect on the immune system. During treatment, patients may be at risk of infection, especially upper respiratory tract infection or other bacterial or viral infections. Therefore, during medication, patients need to pay attention to infection prevention, undergo regular physical examinations, and seek medical treatment promptly when symptoms of infection appear. Doctors may recommend that patients get certain vaccinations during treatment, especially flu and pneumonia vaccines, to help reduce the risk of infection.

Secondly, fostatinib may have certain effects on the liver. During the use of fostatinib, patients should have regular monitoring of liver function, especially liver enzyme levels. If the patient develops jaundice, right upper quadrant pain, or other symptoms of abnormal liver function, the medication should be stopped immediately and necessary examinations should be performed. Patients with abnormal liver function need to be particularly careful. Doctors will adjust the dose or suspend treatment based on the patient's liver function.

In addition, fostatinib may cause an increase in blood pressure. Clinical studies have shown that some patients may develop mild to moderate hypertension while receiving fostatinib. Therefore, patients need to monitor their blood pressure regularly during treatment to keep it within the normal range. If blood pressure is too high, patients may need antihypertensive treatment or a dose adjustment of fostatinib.

During medication, patients should also closely monitor platelet counts and other hematological indicators. Although fostatinib is effective in increasing platelet counts, individual differences may result in different therapeutic effects. Regular blood tests help doctors evaluate the effectiveness of treatment in a timely manner and adjust treatment plans as needed.

Reference materials:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=21149cc3-049b-43e2-b141-c9499160556c