Storage conditions of aprocitentan and methods to avoid reduction in efficacy

In recent years, as the field of hypertension treatment continues to update, the multi-receptor endothelin receptor antagonist aprecitentan (Aprocitentan) has attracted attention due to its research progress in resistant hypertension. While many patients understand the efficacy, they also begin to pay special attention to the storage conditions of drugs, because improper storage will directly affect the stability of drug efficacy. As the weather changes, humidity rises, and patients store more medications at home, how to properly store Aprecitentan has gradually become a hot issue.

Aprecitentan is usually supplied in the form of tablets. According to the drug instructions and the stability characteristics of common small molecule oral drugs, it is recommended to store it in a room temperature, dry and dark environment at 20–25℃. High temperature will accelerate the decomposition of the drug, and a humid environment may cause the tablets to absorb moisture, become soft and even discolor, so it is not recommended to place them in the bathroom, kitchen, or in direct sunlight. If you are in an area with high temperatures in summer, you can put the medicine in a cool place, but it is not recommended to put it in the refrigerator because the temperature and humidity in the refrigerator fluctuate greatly, which may easily cause structural damage to the tablets.

In order to avoid reducing the efficacy of the medicine, patients should try to keep the original packaging for storage. The original packaging bottle or blister usually has an oxygen- and moisture-proof design, which can significantly improve stability. After opening the bottle cap, seal it tightly immediately to avoid oxidation of the active ingredients caused by prolonged exposure to air. If it is packed in a blister, only squeeze out the one pill you need to take at a time. Do not cut it and place it in advance. In addition, avoid mixing different drugs into the same medicine box, because volatile matter and moisture may interact with each other and reduce stability. This is also a detail that many patients tend to overlook.

During daily use, if you find that Aprecitentan tablets have abnormal color, surface spots, mold, chipping, or odor changes , you should stop using it and consult your pharmacist in time. If there are children or pets in the family, medicines should also be placed in a safe place to avoid accidental ingestion. Generally speaking, as long as it is stored according to the instructions, kept dry and the temperature is stable, the efficacy of aprecitentan can be guaranteed to the greatest extent, making the treatment process of resistant hypertension safer and more reliable.

Reference materials:https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/217686s000lbl.pdf