Things to note before and after taking aprocitentan and safe medication tips

Aprocitentan is a new oral antihypertensive drug that mainly exerts antihypertensive effects by antagonizing endothelin receptors. Before using this medicine, patients should fully understand their health status and past medical history, especially kidney function, liver function and blood pressure control. For patients with heart failure, renal insufficiency or electrolyte disorders, medication risks need to be assessed under the guidance of a doctor, and the dose should be adjusted or corresponding monitoring measures taken if necessary to ensure safety.

While taking aprecitentan, blood pressure and blood indicators should be monitored regularly, especially when diuretics, ACE inhibitors, or ARBs are used in combination. Because these drugs may have synergistic antihypertensive effects with aprecitentan, increasing the risk of hypotension or electrolyte abnormalities. When patients experience symptoms such as dizziness, fatigue, or palpitations, they should promptly inform their doctor so that the dosage can be adjusted or symptomatic treatment can be taken. Maintaining a good lifestyle, including a reasonable diet, regular exercise, and quitting smoking and limiting alcohol, can also help medications achieve the best antihypertensive effect.

Aprecitentan may interact with other drugs, such asCYP3A4 Metabolism-related drugs may affect its blood concentration, thereby changing the efficacy or increasing the risk of adverse reactions. Patients should truthfully inform their doctors of all prescription drugs, over-the-counter drugs and health care products they are using before taking medication, and avoid adjusting or superimposing other drugs on their own. At the same time, regular follow-up visits should be followed as directed by the doctor, and the dosage should be adjusted in a timely manner to prevent overdose or insufficient efficacy.

Caution is also required when discontinuing medication or changing treatment regimens. Patients should not stop medication suddenly on their own to avoid a rebound in blood pressure or worsening of the condition. They should gradually adjust or replace other antihypertensive drugs under the guidance of a doctor. In addition, for pregnant women, lactating women, or patients planning pregnancy, the medication regimen should be determined after a doctor's evaluation. Overall, following professional medical advice, regular monitoring and paying attention to lifestyle management are the keys to ensuring the safe and effective use of aprecitentan.

Reference materials:https://en.wikipedia.org/wiki/Aprocitentan