Has anyone used imported obeticholic acid (Obeticholic) and found it effective?

Obeticholic acid is a farnesoid X receptor (FXR) agonist indicated for the treatment of primary biliary cholangitis (PBC), particularly in patients who have an inadequate response to or intolerance to conventional treatments such as ursodeoxycholic acid (UDCA). Although obeticholic acid is not yet available in China, it has been approved in many countries and regions around the world and has shown significant efficacy in the treatment of PBC.

The main function of obeticholic acid is to regulate the metabolism of bile acids by activating the farnesoidX receptor (FXR), thereby reducing the accumulation of bile acids in the liver, relieving the inflammatory response of the liver, and improving the symptoms of primary biliary cholangitis. Obeticholic acid is recommended as part of combination therapy for patients with PBC who do not respond well to ursodeoxycholic acid (UDCA), while for patients who cannot tolerate UDCA, obeticholic acid can be used alone.

According to clinical experience, obeticholic acid has shown positive effects in improving liver function, reducing serum bile acid levels and improving clinical symptoms in patients with primary biliary cholangitis. Many patients reported that after using obeticholic acid, the bile acid levels in the body were significantly controlled, symptoms such as fatigue and itching were relieved, and the overall quality of life was improved. Especially for patients who cannot tolerate UDCA, obeticholic acid provides an effective treatment option to help them control their condition and avoid worsening of the condition.

However, although obeticholic acid is effective, its use may also be associated with some side effects, such as itching, abdominal pain, and fatigue. These side effects are usually temporary and will subside with continued use of the drug or with dosage adjustments. Some patients may need to adjust their medication regimen or conduct monitoring under the guidance of a doctor to ensure the safety of treatment.

Reference materials:https://en.wikipedia.org/wiki/Obeticholic_acid