Detailed analysis of indications and market information for Guanfacine

Guanfacine is a selective α2A receptor agonist that affects the function of the prefrontal cortex primarily by modulating neurotransmitter activity in the central nervous system, thereby improving attention, impulse control, and behavioral regulation. Clinically, guanfacine is mainly used to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents, especially for patients with impulsive and aggressive behaviors. In addition, it can also be used as an auxiliary treatment for hypertension, but in modern clinical practice, indications for hypertension are relatively rare.

In terms of indications, guanfacine can be used as a monotherapy or as part of a combination treatment regimen. When used in combination with stimulant drugs (such as methylphenidate), it can enhance the control effect on hyperactive and impulsive behaviors. Doctors will develop an individualized medication plan based on the patient's age, weight, severity of illness, and response to other medications. The dosage needs to be adjusted gradually during medication to achieve optimal efficacy and reduce adverse reactions such as hypotension, drowsiness or dizziness.

Regarding market information, the original drug of guanfacine has not yet been launched in mainland China, so domestic patients cannot obtain formal prescriptions through hospitals or pharmacies. In foreign markets, common original research versions include the Japanese version, with the main specifications being 1mg×140 tablets and 3mg×140 tablets. A box of 1 mg × 140 tablets is priced at approximately RMB 3,000. The specific price may vary due to exchange rate fluctuations and channel differences. Since the original drugs are purchased across borders, the overall cost also needs to consider transportation, tariffs and other related expenses.
In terms of drug purchase and usage tips, since it is not yet available on the market and covered by medical insurance in China, patients who obtain guanfacine through overseas channels should carefully choose formal supply channels to avoid counterfeit drugs or drugs of substandard quality. During use, you must strictly follow medical advice, regularly follow up on changes in blood pressure, heart rate, and behavioral symptoms, and adjust the dosage or discontinue medication in a timely manner. At the same time, pregnant women and lactating women should avoid using it, and patients of childbearing age should take effective contraceptive measures. Reasonable assessment of efficacy and risks, combined with physician guidance, can ensure medication safety and optimize treatment effects.
Reference: https://medlineplus.gov/druginfo/meds/a694009.html