Reasons and countermeasures for weight gain after 5 days of discontinuation of Tilpotide/Tisiparatide (Mufenda)

Tilpotide (tilsiparatide) is a dual receptor agonist drug used for weight management and diabetes control. It can significantly suppress appetite and improve blood sugar levels in clinical practice. When patients gain weight 5 days after stopping the drug, the main reason is related to the disappearance of the pharmacological effect of the drug. Tisiparatide delays gastric emptying, increases satiety, and improves insulin sensitivity by simulating the effects of GLP-1 and GIP hormones. Once the drug is discontinued, these effects rapidly weaken, appetite returns, and food intake may increase, leading to weight regain.

In addition to increased appetite, water and salt retention can also be a factor in short-term weight gain. When tilsiparatide is used for a long time, patients tend to have a more reasonable diet, with a low-calorie diet and high fiber intake helping to maintain weight. After discontinuation of medication, loosening of dietary control and resumption of normal living and eating habits may result in a short-term increase in energy intake, resulting in weight gain. Additionally, slight changes in metabolic rate may exacerbate weight gain trends.

To deal with weight regain, you first need to control total calorie intake through dietary management, continue to maintain a high-fiber, low-sugar, and low-fat diet structure, and at the same time divide meals into small portions to avoid consuming too many calories at one time. Secondly, increasing the amount of daily exercise, especially aerobic exercise and strength training, can increase the basal metabolic rate and help burn excess calories. In addition, maintaining a regular daily routine, adequate sleep and a good mental state will also help stabilize your weight.

If weight gain is significant and accompanied by blood sugar fluctuations or other uncomfortable symptoms, you should consult your doctor promptly to evaluate whether you need to restart tilsiparatide treatment or adjust other blood sugar-lowering programs/Weight loss program. Depending on the patient's specific situation, the doctor may recommend a gradual return to medication or weight control through a combination of diet, exercise, and medication management. In short, short-term weight gain after drug withdrawal is a common reaction, and through scientific management and professional guidance, it can be effectively controlled in most cases.

Reference:https://en.wikipedia.org/wiki/Tirzepatide