The correct way to take neratinib/neratinib (He Li'an)

The efficacy of neratinib/neratinib is closely related to its standardized dosage, which is also a focus repeatedly emphasized in overseas medication guidelines. As an oral small molecule targeted drug, its dosage, taking time and combination drug strategy directly affect the therapeutic effect and tolerability. Therefore, understanding and following the correct taking method is an important prerequisite to ensure the continuity of treatment.

In the extended adjuvant treatment of HER2-positive early-stage breast cancer , the recommended dose of neratinib is 240 mg per day, that is, 6 40 mg tablets taken orally at one time, which need to be taken with food. Overseas experience believes that taking it with meals can help stabilize drug absorption and reduce gastrointestinal irritation to a certain extent. The treatment is usually initiated after completion of previous standard anti-HER2 therapy and lasts up to one year, with the goal of further reducing the risk of relapse rather than short-term symptom improvement.

In the treatment of advanced or metastatic breast cancer, neratinib is often used in combination with capecitabine in a 21-day dosing cycle. On days 1 to 21 of each cycle, 240 mg of neratinib was taken orally daily, combined with oral capecitabine on days 1 to 14, followed by a short rest period until disease progression or intolerable adverse reactions occurred. This cyclical plan is relatively mature in overseas cancer treatment practice, emphasizing the importance of individualized adjustment.

In recent years, dose escalation strategies have received increasing attention. Some patients have poor tolerance to the standard dose at the beginning of treatment. Doctors may recommend gradually increasing the dose of neratinib within the first two weeks, and flexibly adjust it according to the patient's gastrointestinal reaction and overall tolerance. This approach is believed to help improve the sustainability of long-term medication and also embodies the concept of precision medication.

Reference materials:https://en.wikipedia.org/wiki/Neratinib