Is there a big difference between the Lucius version of Stiripentol and the original drug?

Stiripentol is an anti-epileptic drug used to treat seizures associated with Dravet syndrome. Its original drug is produced by Biocodex SA and is available in many markets around the world. However, as market demand increased, some generic drugs also entered the market, including Lucius version (generally produced in Laos). These generic drugs usually have lower prices, but their differences from the brand-name drugs are still a topic of concern for patients and doctors.

In terms of the composition and mechanism of action of the drug, the Lucius version of the generic drug is basically the same as the original drug. Both contain the same active ingredient - stiripentol, and their mechanism of action is the same, which is to inhibit epileptic seizures by enhancing the action of GABA (γ-aminobutyric acid) receptors. By enhancing the activity of GABA receptors, geltipentol can effectively regulate nerve conduction and reduce nerve excitation, thereby controlling epileptic seizures. It especially plays an important role in the treatment of refractory epilepsy such as Dravet syndrome.

However, although the Lucius version of the generic drug is identical in composition and mechanism to the original drug, there are still some differences, especially in the production process of the drug and the selection of excipients. Since generic drugs usually use simpler production processes or lower-cost raw materials, there may be slight differences in the stability, absorption rate and side effects of the drug. These differences usually do not affect the main therapeutic effect of the drug.

In addition, in terms of price, the Lucius version of the generic drug is significantly lower than the original drug. According to market conditions, the price of Lucius version of stiripentol is approximately RMB 3,000, while the price of the original drug is usually between RMB 5,000 and RMB 9,000. The specific price depends on different regions and exchange rate fluctuations. The difference in price makes generic drugs a choice for some patients with poor economic conditions, especially in some developing countries and regions, where the affordability of generic drugs is more advantageous.

Reference materials:https://www.diacomit.com/