Maribavir/Yitazhi side effect grading

Maribavir (Maribavir) is a new oral drug against cytomegalovirus (CMV). It is generally well tolerated, but side effects may still occur to varying degrees. The most common side effects include dysgeusia, nausea, diarrhea, vomiting, and mild fatigue. Dysgeusia usually manifests as changes in the perception of sweet, salty, sour, and bitter. Some patients may experience a metallic taste in the mouth or an abnormal taste of food. Although this side effect is not life-threatening, it may affect the patient's appetite and daily eating habits. Mild nausea and diarrhea can usually be relieved by adjusting diet, taking medications in divided doses, or supplementing with symptomatic treatment.

More serious side effects include persistent diarrhea, nausea, and vomiting, which may lead to weight loss and malnutrition. In some transplant patients receiving immunosuppressive drugs, maribabavir may cause increased blood levels or affect immune drug metabolism, requiring close monitoring of blood markers. Such serious side effects can usually be alleviated through dose adjustment or symptomatic treatment. Clinical guidelines recommend that when obvious discomfort occurs, a doctor should be contacted immediately for evaluation to avoid complications.

Grading of side effects is very important in clinical management. Mild side effects generally do not require discontinuation of treatment, but require close observation and lifestyle intervention; moderate side effects may require dosage adjustment or temporary extension of the medication interval; severe side effects require suspension of medication and corresponding medical intervention, such as rehydration, medication adjustment, or hospitalization for observation. Multi-center clinical experience shows that through standardized management, the vast majority of patients can continue to complete the course of treatment while maintaining good virological control.

In summary, the side effects of maribavir are predictable and mostly controllable. Through symptomatic treatment, dose adjustment, and regular blood and virological monitoring, the impact of adverse events can be reduced while ensuring efficacy.

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