Does taking decavatinib affect liver function?

Deucravacitinib is an oral selective TYK2 inhibitor mainly used to treat moderate to severe psoriasis and some autoimmune diseases. Since its metabolism mainly relies on liver enzymes, the state of liver function has an important impact on the safety and efficacy of the drug during administration. Clinical data show that the incidence of liver function abnormalities is low in most patients when used at conventional doses, but close attention is still required.

While taking deuterated colexitinib, a small number of patients may experience elevated serum aminotransferases, including ALT and AST increases. Most of these cases are mild to moderate and usually recover gradually over time without stopping the medication, but some patients with severe elevations may need to suspend medication or adjust the dose. Therefore, doctors will assess the patient's liver function status before taking medication and regularly monitor liver function indicators during treatment in order to detect abnormalities early and take intervention measures.

For patients with existing liver function abnormalities or chronic liver disease, deuterated colexitinib should be used with extreme caution. Physicians may choose a lower starting dose and increase the frequency of follow-up visits to reduce the potential burden of the drug on the liver. At the same time, the concurrent use of drugs that may increase the risk of liver damage, such as some antifungals, antituberculosis drugs, or high-dose acetaminophen, should be avoided to reduce the probability of hepatotoxicity.

Overall, deuterated colexitinib generally has a mild effect on liver function, but there are still potential risks. During the period of medication, patients should regularly monitor liver function according to the doctor's guidance, and pay attention to seek medical treatment promptly if abnormal symptoms such as fatigue, jaundice, or loss of appetite occur. Reasonable dose adjustment and standardized monitoring can ensure the efficacy while minimizing the impact on the liver and ensuring safe medication.

Reference materials:https://www.drugs.com/