What is the approximate price of a box of Nintedanib on the market?

Nintedanib (Nintedanib) is a multi-target tyrosine kinase inhibitor that mainly acts on signaling pathways such as VEGFR, FGFR and PDGFR, and has a significant effect in anti-fibrosis and inhibiting tumor angiogenesis. The drug is currently widely used around the world to treat diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-related interstitial lung disease (SSc-ILD). By blocking cytokine signaling, nintedanib can delay the progression of lung tissue fibrosis, improve lung function, and prolong patient survival.

In China, nintedanib is approved for marketing under the trade name "Ofev". The approved dosage form is nintedanib ethanesulfonate soft capsules, with two specifications: 100mg and 150mg. The drug has been included in the National Medical Insurance Category B Catalog, and patients who meet the criteria for idiopathic pulmonary fibrosis can be reimbursed on a proportional basis. However, patients who are not indicated or do not meet the medical insurance reimbursement standards still need to purchase it at their own expense. The current selling price in domestic pharmacies and formal channels is about: 100mg × 30 capsules are priced at more than 4,000 yuan , and 150mg × 30 capsules are priced at more than 5,000 yuan. The specific prices fluctuate slightly due to differences in regions, channels and medical insurance policies.

In the international market, the original drug of nintedanib is also produced by Boehringer Ingelheim, but some countries such as India and Türkiye also have authorized or generic versions. The specifications of the original research version in India and Turkey are usually 100 mg × 60 capsules or 150 mg × 60 capsules. The price per box is about RMB 4,000 to 5,000 yuan, which is overall slightly lower than the domestic original research version. At the same time, the ingredients of generic drugs in some countries are the same as those of the original drugs, and the efficacy is similar, but the selling price has dropped significantly, about 600 to 800 yuan per box. However, it should be noted that there are differences in drug quality standards and regulatory requirements in different countries. Patients should give priority to purchasing through formal medical channels to avoid risks caused by purchasing drugs through non-compliant channels.

Reference materials:https://en.wikipedia.org/wiki/Nintedanib