The correct way and precautions for taking Anamorelin

Anamorelin (Anamorelin) is an oral small molecule drug. Its main mechanism of action is to activate ghrelin receptors, promote increased appetite and stimulate the secretion of growth hormone (GH) and insulin-like growth factor (IGF-1), thereby improving the nutritional status and muscle mass of cancer patients. Correctly mastering the taking methods and precautions is the key to ensuring the effectiveness of the medicine and reducing adverse reactions. According to Japanese and European and American guidelines, the standard recommended dose of anamulin is 100 mg once a day, taken orally, and needs to be taken on an empty stomach, that is, at least 1 hour before a meal or 2 hours after a meal for the best effect.

The reason for taking the drug on an empty stomach is that the absorption of anamulin is significantly affected by food. If taken after meals, the bioavailability of the drug will decrease and affect the stability of the drug effect. Therefore, it is very important to maintain a fixed medication time. Patients should take it at the same time every day to maintain a balanced drug concentration in the body. Tablets should be swallowed whole and should not be chewed or crushed to prevent the drug structure from being damaged and affecting the release rate. If the patient accidentally takes an overdose, he or she should contact a doctor immediately, as high doses may cause blood sugar fluctuations or abnormal heart rate and other reactions.

Anamorelin is generally well tolerated, but you still need to pay attention to some potential side effects during use, such as mild nausea, bloating, mild elevation of blood sugar, mild fatigue and other symptoms, which are usually reversible. In patients with diabetes, blood glucose should be monitored closely because drug-stimulated increases in IGF-1 may alter insulin sensitivity. In addition, patients with impaired liver and kidney function need to use it with caution under the guidance of a doctor, because the metabolic pathway mainly passes through the liver. If liver enzymes are elevated or jaundice appears, they should be reviewed in time.

Special reminder that Anamorelin is not a "weight gain drug" or a "muscle building supplement", but a professional drug for cancer cachexia. During use, patients should combine a high-protein diet and rehabilitation training guided by a nutritionist to achieve the best results.

Reference materials:https://pmc.ncbi.nlm.nih.gov/articles/PMC4677053/