What are the contraindications and situations that require special attention when using axitinib (Inlida)?

Axitinib (Axitinib) is an oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, mainly used to treat advanced renal cell carcinoma (RCC). It exerts anti-tumor effects by inhibiting the VEGFR signaling pathway and blocking tumor angiogenesis and tumor growth. Although the efficacy is significant, there are certain contraindications and situations that require special attention during use. Patients should use the medication under the guidance of a doctor.

Axitinib is contraindicated in pregnant and lactating women. Medications may be potentially toxic to the fetus or infant, affect fetal development, or pass into the infant through breast milk. Therefore, female patients must take effective contraceptive measures during treatment and follow medical advice to delay pregnancy after stopping the drug; male patients also need to take contraceptive measures to prevent the drug from affecting reproductive health through sperm.

Use axitinib with caution in patients with severe hepatic or renal impairment. Drugs are mainly metabolized by the liver. Hepatic insufficiency may lead to an increase in blood drug concentration and increase the risk of toxic and side effects. Patients with abnormal renal function may also increase the possibility of drug accumulation, resulting in hypertension, proteinuria or other adverse reactions. Liver and kidney function should be assessed before use, and dosage or monitoring frequency should be adjusted according to physician recommendations.

Patients also need to pay special attention to the risks of hypertension, bleeding, thrombosis and gastrointestinal perforation while taking axitinib. Drugs may cause blood pressure to rise, so blood pressure needs to be monitored regularly and controlled with antihypertensive drugs if necessary; patients with peptic ulcers or bleeding tendencies should use them with caution to prevent serious complications. At the same time, if persistent abdominal pain, black stools or abnormal bleeding occur, you should seek medical treatment immediately. Standardized monitoring and individualized management are key to ensuring the safe use of axitinib.

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