Can Gilteritinib be taken with food and dietary precautions

Gilteritinib (Gilteritinib) is an oral FLT3 inhibitor, mainly used to treat FLT3 mutant acute myeloid leukemia (AML). In the process of daily taking medicine, whether it is taken with food will have a certain impact on the absorption and efficacy of the medicine. Therefore, patients need to know the correct way of taking medicine and dietary precautions.

According to the clinical labeling, giritinib can be taken with or without food, and drug absorption is not significantly affected by food. However, to reduce gastrointestinal discomfort, such as nausea, abdominal pain, or indigestion, many patients choose to take it with a meal. Especially for patients with sensitive gastrointestinal tracts, it is recommended to take it with mild, easily digestible food to improve tolerance.

In terms of diet, patients should avoid high-fat, greasy or spicy foods to reduce the occurrence of digestive system side effects. In addition, try not to take it with grapefruit or grapefruit juice, because the ingredients contained in grapefruit may affect the activity of liver CYP3A enzyme, thereby changing the blood concentration of giritinib, affecting the efficacy or increasing the risk of side effects.

Generally speaking, you can flexibly choose to take gilitinib with or without food, but to ensure the safety and tolerability of the drug, it is recommended to follow the instructions of your doctor or pharmacist. During the treatment period, maintaining a regular diet, avoiding high-risk foods, and monitoring blood indicators and body reactions can maximize the efficacy and safety of giritinib.

Reference materials:https://www.drugs.com/