Can I take ibuprofen after taking trametinib?

While taking Trametinib (Trametinib), avoid concurrent use with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, unless directed by a doctor. Ibuprofen may increase trametinib plasma concentrations and increase the risk of adverse effects such as bleeding or gastrointestinal ulceration. If you need to use ibuprofen and trametinib together, be sure to talk to your doctor first. Your doctor will evaluate your condition and medications and adjust your treatment plan as needed. During treatment, if you need to use other drugs, always follow your doctor's instructions and avoid adjusting drug dosages or combining drugs on your own to avoid increasing unnecessary risks.