Why does rash occur on trametinib?

Trametinib is a targeted therapy drug used to treat certain types of cancer, such as malignant melanoma and non-small cell lung cancer. Rash is one of the common side effects during trametinib treatment. This side effect may be due to trametinib affecting the physiological functions of the skin, causing skin discomfort. Specifically, trametinib may interfere with the signaling pathways of skin cells, causing abnormal proliferation and differentiation of skin cells, thereby causing rashes. This rash usually presents with symptoms such as skin erythema, itching, dryness, and scaling. Although the rash is not usually life-threatening, it may affect the patient's quality of life and cause discomfort. Therefore, during treatment with trametinib, patients should be regularly monitored and evaluated by their physician and report any symptoms of skin discomfort in a timely manner. Your doctor may recommend that patients take steps to relieve skin discomfort, such as using mild cleansers, moisturizers, and sunscreen. In some cases, your doctor may adjust the medication dose or pause treatment to reduce or eliminate the rash.