Denosumab side effects

DenosumabDenosumabThe most common side effects are joint and muscle pain in the arms or legs. Increased risk of infections such as cellulitis, hypocalcemia (low calcium in the blood), allergic reactions, osteonecrosis of the jaw, and atypical femur fractures. A trial showed a significant increase in eczema and hospital admissions due to skin infections. It has been suggested that the increase in infections under denosumab treatment may be related to RANKL's role in the immune system. RANKL is expressed by T helper cells and is thought to be involved in dendritic cell maturation. Discontinuation of denosumab is associated with increased rebound bone turnover. In rare cases, this can lead to severe hypercalcemia, especially in children.