Vonoprazan action and efficacy

Vonoprazan(Vonoprazan)is a potassium competitive acid blocker(PCAB)+, Vonoprazan is combined with amoxicillin and clarithromycin in a co-packaged product and is indicated for the treatment of Helicobacter pylori (H. pylori) infection in adults. Studies have shown that the combination of vonoprazan, amoxicillin, and clarithromycin can lead to an eradication rate of Helicobacter pylori of approximately 90%. Vonoprazanhas time-independent pharmacokinetics, reaching steady-state concentrations after 3 to 4 days. In patients treated with a single dose of vonoprazan, AUC0-12 hours, Cmax and Tmax was 154.8nanogram hours/ml, 25.2nanogram/ml and 2.5 hours. In patients taking vonoprazan twice daily, AUC0-12 hours, Cmax and Tmax were 272.5ng hours/ml, 37.8ng/ml and 3.0 hours 5 given daily for 7days 10 In patients receiving 40 mg to 40 mg of vonoprazan, AUC and Cmax increased in a dose-proportional manner. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.