Is Osimertinib 9291?

9291 usually refers to Osimertinib mesylate tablets in China, which are different names of Osimertinib. They are all targeted drugs used to treat non-small cell lung cancer (NSCLC). It is also used under other names, such as Osimertinib, AZD9291, Osimertinib, etc., and is also sold under the trade name of Tagrisso. Osimertinib is a potent, orally effective, third-generation EGFR inhibitor that can inhibit the activation of the EGFR signaling pathway, thereby inhibiting the growth of tumor cells. Osimertinib is basically effective in tumors that have acquired resistance to EGFR-TKIs due to the T790M mutation.