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What Ritlecitinib does
Ritlecitinib, the active ingredient in Ritlecitinib, irreversibly inhibits Janus kinase 3 (JAK3) and tyrosine kinases expressed in the kinase family of hepatocellular carcinoma (TEC) by blocking the adenosine triphosphate (ATP) binding site. In vitro, ritexitinib inhibits cytokine-induced STAT phosphorylation mediated by JAK3-dependent receptors and signaling by immune receptors that depend on members of the TEC kinase family. Although JAK inhibitors (such as ritixitinib) may inhibit the inflammatory pathways activated in alopecia areata, their exact mechanisms of action have not been fully elucidated.
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