Are the side effects of Talazoparib serious?

In clinical studies using talazoparib (Talazoparib) to treat breast cancer, the most common side effects included fatigue, nausea, headache, vomiting, hair loss, diarrhea and decreased appetite. In clinical studies of talazopanib combined with enzalutamide in the treatment of prostate cancer, the most common side effects included fatigue, nausea, decreased appetite, fractures, dizziness, and dysgeusia. There is no specific treatment in the case of talazopanib overdose, and the symptoms of overdose have not been established. In case of overdose, discontinue talazopanib therapy, consider gastric decontamination, follow general supportive measures, and treat according to symptoms.