How long does it take to become resistant to Palbociclib?

How long does it take for resistance to Palbociclib to develop after use? It may be one year or two years. The specific resistance time varies from person to person. Studies have shown that patients generally have higher response rates to palbociclib in the early stages of treatment. But over time, tumor cells may develop drug resistance, causing treatment to become less effective or cease. According to palbociclib clinical trial data, patients using palbociclib capsules to treat advanced breast cancer had a median progression-free survival of 24.8 months. Therefore, the longest known period of resistance to palbociclib is about two years.