What is the half-life of Rivaroxaban?

Rivaroxaban is a low-clearance drug, with systemic clearance of approximately 10 liters/hour after intravenous administration in healthy volunteers. In healthy subjects aged 20 to 45 years, the terminal elimination half-life of rivaroxaban is 5 to 9 hours. The absolute bioavailability of rivaroxaban is dose-dependent. For the 2.5mg and 10mg doses, estimates are 80%-100%, independent of food. Rivaroxaban 2.5 mg and 10 mg tablets may be taken with or without food. Rivaroxaban at 20 mg administered in the fasted state has an absolute bioavailability of approximately 66%. Taking rivaroxaban with food can increase the bioavailability of the 20 mg dose. Rivaroxaban15 mg and 20 mg tablets should be taken with food.