Can regorafenib be taken with cephalosporins?

Regorafenib (Regorafenib) and cephalosporins are in different drug classes. Regorafenib is a multi-target inhibitor and cephalosporins are antibiotics, but that doesn't mean there aren't possible interactions between them. Although some antibiotics may affect drug metabolism and clearance, affecting the effectiveness of regorafenib or increasing the risk of adverse effects. For example, coadministration of strong CYP3A4 inducers with regorafenib reduces the plasma concentration of regorafenib, increases the plasma concentration of the active metabolite M-5, and may lead to a decrease in efficacy. Under normal circumstances, patients taking cephalosporins can take regorafenib. However, it is best to do so under the advice or guidance of a doctor to obtain personalized advice.