Does Trametinib have many side effects?

In clinical trials of Trametinib, the most common side effects affecting ≥10% of patients included rash( 57%), diarrhea (43%), lymphedema (32%), dermatitis acneiformis (19%), stomatitis (15%), high blood pressure (15%), abdominal pain(13%), bleeding (13%), dry skin (11%), pruritus (10%), paronychia (10%). Serious adverse reactions affecting ≥2% patients are grade 3 and grade 4 hypertension( 12%), rash (8%), pruritus (2%), stomatitis (2%). In clinical trials, cardiomyopathy was also observed in 11% of patients taking trametinib, and the incidence of rapid pigment epithelial detachment was 0.8%. The incidence of rapid pigment epithelial detachment was 0.8% and interstitial lung disease or pneumonia occurred in 1.8% of patients requiring hospitalization at recommended doses.