How effective is Tofacitinib tablets in treating rheumatoid arthritis?

Tofacitinib (Tofacitinib) is a recent new oral biological agent, which is a JAK inhibitor. Its common indications are rheumatoid arthritis and ankylosing spondylitis, and it is highly effective in psoriatic arthritis. Rheumatoid arthritis is mostly caused by the proliferation and infiltration of rheumatoid T lymphocytes, which secrete a large amount of cytokines, causing synovial cells to proliferate and thicken, produce new blood vessels, form vasculature, corrode cartilage, destroy subchondral bones, and destroy the entire joint to form rheumatoid arthritis. Cytokines play an important role in the pathogenesis of rheumatoid arthritis, and biological agents prepared for them include tumor necrosis factor, interleukin, etc. Tofacitinib can inhibit the levels of multiple cytokines and reduce the levels of cytokines to achieve the purpose of treating rheumatoid arthritis with good results.