Will taking tenofovir alafenamide fumarate tablets (Vemlidy) with food affect its efficacy?

The instructions for tenofovir alafenamide fumarate tablets (Vemlidy) show that when taken orally, tenofovir alafenamide fumarate tablets need to be taken regularly with food, and 25 mg should be taken orally once a day with food. Common adverse reactions are gastrointestinal diseases, such as vomiting, nausea, abdominal pain, etc. Taking tenofovir alafenamide on an empty stomach may aggravate the symptoms of gastrointestinal discomfort. Patients should not increase or decrease the dosage on their own. Otherwise, not only will the efficacy of the disease become worse, but also it will easily have adverse effects on their own health. Before initiating this drug, patients should be tested for HIV-1 infection and assessed for serum creatinine, estimated creatinine clearance, urine glucose, urine protein, and, in patients with chronic kidney disease, serum phosphorus.