Is afatinib a targeted drug?

Yes, afatinib (Afatinib) is a targeted drug. Targeted drugs are a class of drugs designed to target specific cancer cells. They work by interfering with specific biomolecules or signaling pathways within cancer cells, thereby inhibiting the growth and spread of cancer cells with relatively little damage to normal cells. The targeting effect of afatinib is achieved by inhibiting the epidermal growth factor receptor (Epidermal Growth Factor Receptor, EGFR) on tumor cells. EGFR is a receptor tyrosine kinase located on the cell membrane. It plays an important role in regulating cell growth, differentiation and survival. EGFR may be mutated in some tumor cells, leading to its abnormal activation, thereby promoting uncontrolled proliferation of tumor cells.