Why does cycloserine cause psychosis? How to deal with it?

Cycloserine (Cycloserine)As a second-line anti-tuberculosis drug, it works by inhibiting bacterial cell wall synthesis, but its chemical structure easily penetrates the blood-brain barrier and directly interferes with the balance of central neurotransmitters. Patients often experience anxiety, insomnia and even hallucinations after taking the drug, which is related to the drug dose. The risk increases significantly when the blood drug concentration exceeds 30 μg/ml. Coping strategies include: strictly follow the doctor's instructions to control the dose and avoid excessive use; combined with vitamin B6 (50mg daily) can reduce the risk of neurotoxicity; mental symptoms need to be assessed regularly during medication. If mood swings or abnormal behavior occur, you need to contact your doctor immediately to adjust the plan. Additionally, patients should avoid alcohol or high-fat diets.