What are the common side effects of using irinotecan hydrochloride liposome injection? How to prevent and treat it?

Common side effects include gastrointestinal reactions such as diarrhea, nausea, vomiting, and leukopenia, anemia, and thrombocytopenia caused by bone marrow suppression. Compared with traditional irinotecan, liposome preparations may have less gastrointestinal toxicity and bone marrow suppression, but caution is still required. Preventive antiemetics and adequate hydration should be given before and after treatment, and blood routine and liver and kidney functions should be closely monitored. When diarrhea is severe, antidiarrheal drugs should be used promptly and the treatment plan should be adjusted. A very small number of patients may experience infusion reactions or allergic reactions, and the infusion should be stopped immediately and treated accordingly. Patients need to follow the doctor's advice for regular follow-up visits, report physical discomfort in a timely manner, and ensure safe medication use.