How clofazimine turns black

The reason why clofazimine (Clofazimine) causes skin darkening is mainly related to its pharmacological effects. Clofazimine is an antibacterial drug that works mainly by affecting bacterial lipid metabolism and cell membrane structure. At the skin level, clofazimine may cause deposition of lipid particles within the skin, particularly in the skin's macrophages. The absorption of light by these particles causes the skin to gradually darken, forming the so-called "cutaneous pigmentation disease". This phenomenon may not be obvious at the beginning of treatment, but with long-term use of the drug, pigmentation will gradually increase. Although this darkening is usually reversible and skin pigmentation may gradually decrease after treatment is discontinued, individual reactions may vary and some people may experience persistent pigmentation. Therefore, while using clofazimine, it is recommended to avoid overexposure to the sun and to check skin condition regularly so that treatment options can be adjusted and skin reactions managed in a timely manner.