Is it easy to develop drug resistance to cycloserine?

As an anti-tuberculosis drug, cycloserine has a certain risk of developing drug resistance, especially if it is used for a long time or inappropriately. The development of drug resistance mainly results from the adaptive changes of Mycobacterium tuberculosis to drugs, which may lead to the gradual reduction of the drug's killing effect on bacteria. To reduce the development of cycloserine resistance, health care providers often recommend combination therapy with other effective anti-TB drugs, especially for patients with multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). In addition, following correct dosing instructions and strict treatment regimens, such as correct dosage and regular monitoring of efficacy, are crucial to prevent the development of drug resistance. In addition, patients and doctors should work closely together to ensure compliance and monitoring during treatment, and adjust treatment plans in a timely manner to reduce the risk of drug resistance. Overall, through scientific and rational use and effective management, the development of cycloserine resistance can be effectively reduced and patients can obtain the best treatment effect and prognosis.