Will drug resistance develop after discontinuation of linezolid?

There are some complex considerations regarding the impact of linezolid (Linezolid) in tuberculosis treatment as to whether drug resistance will result after discontinuation of the drug. The resistance of Mycobacterium tuberculosis (TB) to linezolid is mainly related to the way it is used and the concentration of the drug during treatment. In tuberculosis treatment, the development of drug resistance often involves multiple factors, including whether the patient takes the drug on time and correctly, whether the drug is adequately absorbed and effective concentrations are maintained. If patients do not continue to receive linezolid during treatment or do not achieve adequate drug concentrations, tuberculosis bacteria may gradually develop resistance to linezolid. In order to minimize the development of drug resistance, doctors usually advise patients to strictly follow the treatment plan and complete the entire course of treatment without stopping or changing medication midway. In addition, TB treatment is often a combination regimen, of which linezolid is often used as part of the regimen, to reduce the risk of drug resistance and increase efficacy.