Lurbinectedin’s mechanism of action

Lurbinectedin (Lurbinectedin) is a DNA alkylating agent. It covalently binds to guanine residues in the minor groove of DNA, forming an adduct that bends the DNA helix toward the major groove. This process triggers a cascade of events that affects the activity of transcription factors and impairs DNA repair pathways, ultimately leading to double-stranded DNA breaks and eventual cell death. Rubicatin exerts its chemotherapeutic activity by covalently binding to DNA, causing double-stranded DNA breaks and subsequent cell death. Other mechanisms of action include inhibitingRNA polymerase II activity, inactivating Ewing sarcoma oncoprotein (EWS-FL11) through nuclear redistribution, and inhibiting human monocyte activity and macrophage infiltration into tumor tissue.