雷帕鸣(西罗莫司片)哪里可以买的到

(Sirolimus tablets) Where can I buy it? Rapamin (sirolimus tablets) is an oral drug used to prevent organ rejection in patients aged 13 or above who have received kidney transplants. It was approved by the US FDA in September 1999. In 2003, rapamin (sirolimus/sirolimus) was marketed in China and used to treat kidney transplant patients with remarkable results. After Rapamin is approved for marketing in my country, patients can buy it in some domestic hospitals with a prescription issued by a doctor.

Rapamin (sirolimus tablets) suppresses the body's immune function by affecting unique cell signaling pathways. Rapamin and FK506 share the same receptor in the body, namely FK506 immune binding protein (FKBP). After rapamin binds to FKBP, on the one hand, it inhibits the activation of 70-KSU6 kinase (p7), preventing the ribosome 40S subunit S6 protein from phosphorylating g7, affecting protein synthesis; on the other hand, it inhibits cyclin D2, D3 and cell cycle-dependent kinase (cdk4). The expression of cdk6 and the activation of Cyclin E-cdk2 complex cause cells to arrest in the middle and late stages of GI and cannot continue to proliferate.

The direct target of rapamycin (sirolimus tablets) may be a protein mammalian'rOR (mTOR) that has a homologous sequence to phospholipid phthaloinositide kinase. That is, the combination product of the sirolimus and FKBP complex and mTOR can block the immune response triggered by the activation of mTOR by H, -2, U, -15 or CD28/B7 costimulatory pathways, thus exerting a powerful immunosuppressive effect. 

In addition to the domestically marketed medicine (sirolimus tablets), India has also launched the generic version of rapamycin produced by Biocon Pharmaceuticals. The price is relatively low. The specifications are 1mgx10 tablets and the price is about $200. Patients can consult their medical companions to purchase.

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