雷帕鸣(西罗莫司片)每天的具体用量

(Sirolimus tablets) is an immunosuppressant that inhibits the activation and proliferation of T lymphocytes by inhibiting their response to stimulation by antigens and cytokines (IL-2, IL-4 and IL-15). For patients after kidney transplantation, rapamycin is an effective treatment option to prevent organ rejection. Before starting a drug treatment, it is essential to carefully understand how to use it. The following is the usage and dosage of rapamycin, I hope it will be helpful to you.

Rapamin is administered orally once daily. It is suitable for patients 13 years of age or older who have received kidney transplantation. The safety and effectiveness in patients younger than 13 years of age are unknown. If use is necessary, blood trough concentration monitoring should be performed.

After transplantation, rapamin (sirolimus tablets) should be started as early as possible. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients.

It should be noted that grapefruit juice can slow down the metabolism of rapamin regulated by CYP3A4 and therefore should not be used for administration or dilution of this drug. Use is contraindicated if the patient is allergic to sirolimus, sirolimus derivatives, or any component of this oral solution. The drug may cause harm to the fetus and should not be used by pregnant and breastfeeding women.

(Sirolimus Tablets) Common side effects during treatment include lymphocele, peripheral edema, abdominal pain, diarrhea, hypokalemia, increased lactate dehydrogenase, acne, and urinary tract infection; very common at higher doses: anemia, hypercholesterolemia, thrombocytopenia, and hypertriesteremia (hyperlipidemia). In order to reduce the impact of side effects on patients, please strictly follow your doctor's instructions and use medications correctly during treatment.

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