雷帕鸣(西罗莫司片)效果怎么样

Organ transplantation has saved the lives of many people. From critical illness to return to normal life, what needs to be paid attention to is the rejection reaction after organ transplantation. Instead, prescription drugs, the generic name is sirolimus tablets, are suitable for patients who have received kidney transplants to prevent organ rejection. So what is the effect of Rapamin (sirolimus tablets)?

The main component of rapamycin is sirolimus. Sirolimus inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

When using rapamycin (sirolimus tablets), it is recommended to use it together with cyclosporine and corticosteroids. Take orally, once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose should be taken, which is 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are satisfactory, the therapeutic benefit of doses above 2 mg is unclear for kidney transplant patients. Daily administration of rapamin is recommended in combination with cyclosporine and corticosteroids. The overall safety of patients taking 2 mg of rapamin (sirolimus tablets) daily is better than that of patients taking 5 mg of rapamin (sirolimus tablets) daily.

Side effects in the digestive system are very common after patients take Rapamin (sirolimus tablets): abdominal pain, diarrhea, constipation, nausea; common: stomatitis, ascites; rare: pancreatitis, it is recommended to take it according to the doctor's advice. (Sirolimus Tablets) is contraindicated in patients who are allergic to sirolimus, sirolimus derivatives, or to any ingredients in this product. Kidney transplant patients should not overeat, and should not eat too much of foods that are prone to allergies, such as shrimp, crabs, shallow-sea cultured shellfish, etc.

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