西罗莫司片使用说明

[Common name] (Repamin), sirolimus

[Indications/Functions and Indications] Sirolimus Tablets (Rapamin) are suitable for patients undergoing kidney transplantation to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids.

[Specification model] 0.5mg tablet/1mg tablet/oral liquid

【Storage】Normal temperature, light-shielding, airtight

【Usage and Dosage】

Sirolimus tablets (rapamin) are taken orally, once a day.

It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day.

Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients.

The overall safety profile of patients taking sirolimus tablets (rapamin) 2 mg daily is better than that of patients taking sirolimus tablets (rapamin) 5 mg daily.

【Adverse reactions】

Very common (incidence >10% according to International Council of Medical Organization frequency classification): lymphocele, peripheral edema, abdominal pain, diarrhea, hypokalemia, increased lactate dehydrogenase, acne, urinary tract infection; very common at higher doses: anemia, hypercholesterolemia, thrombocytopenia, hypertriglyceridemia (hyperlipidemia). Store in a cool, dry, dark environment.

【Taboo】

It is contraindicated for use in patients who are allergic to sirolimus, sirolimus derivatives, or any component of this drug's oral solution, and to pregnant and lactating women.

【Notes】

Grapefruit juice slows the metabolism of this drug, which is regulated by CYP3A4, and should not be used to administer or dilute this drug. It is recommended to take (rapamin) 4 hours after taking cyclosporine oral solution (improved version) and/or cyclosporine capsules (improved version). Please read the instructions carefully and use it as directed by your doctor.

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