西罗莫司片2020年售价多少？

(Lei Panming) How much will it cost in 2020? Let’s find out. Sirolimus tablets (rapamin) are suitable for patients undergoing kidney transplantation. It is recommended to be used in combination with cyclosporine and corticosteroids to prevent organ rejection. Sirolimus tablets (rapamin) inhibit the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus (rapamin) binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian Siros BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from G1 to S phase in the cell cycle. The safety and efficacy of sirolimus tablets (rapamin) in children under 13 years of age have not been determined. If used in children under 13 years of age, it is recommended to monitor the whole blood trough concentration of sirolimus tablets (rapamin).

At the same time, this type of compound also has the potential to treat stroke, neurodegenerative diseases, Parkinson's syndrome, Alzheimer's disease, etc. Harrison et al. reported in Nature magazine in July 2009 that rapamycin can extend the lifespan of aging mammalian mice, which immediately aroused widespread attention and high interest among scientists from all over the world. The American "Science" magazine selected this research result as one of the top ten scientific advances of the year.

Because sirolimus tablets (rapamin) have low nephrotoxicity, they can maintain long-term stability of renal function, and they can also reduce the incidence of tumors in transplant patients while suppressing immunity. It is generally believed that sirolimus tablets (rapamin) bind to FKBP12, and the RAPA-FKBP12 complex binds to the mammalian target of rapamycin (mTOR), inhibiting the proliferation of T lymphocytes and B lymphocytes caused by various stimuli, causing cells to stay in the late Gl phase of the cell cycle, and preventing these cells from entering the S phase.

According to the medical companion brigade (Lei Paming), it was around 1800. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

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