西罗莫司片对肾移植有多大效果？

How effective is (sirolimus) in kidney transplantation? Sirolimus tablets are suitable for patients receiving kidney transplants to prevent organ rejection. It is recommended that sirolimus tablets be used in combination with cyclosporine and corticosteroids.

To evaluate the safety and efficacy of sirolimus tablets in preventing organ rejection after kidney transplantation, two randomized, double-blind, multicenter controlled trials were conducted. The two trials compared two doses of sirolimus oral solution (2 mg and 5 mg once daily) with azathioprine (Trial 1) or placebo (Trial 2) while taking cyclosporine and corticosteroids. Trial 1 was conducted at 38 research sites in the United States, with 719 patients participating.

Random allocation after transplantation: 284 patients received sirolimus tablets (sirolimus) 2 mg/d, 274 patients received sirolimus tablets (sirolimus) 5 mg/d, and 161 patients received azathioprine 2-3 mg/kg/d. Trial 2 was conducted at 34 research units in Australia, Canada, Europe and the United States, with 576 patients participating. Before transplantation, 227 patients received sirolimus 2 mg/d, 219 received sirolimus 5 mg/d, and 130 received placebo. In both trials, antilymphocyte antibody induction therapy was contraindicated. In both trials, the primary efficacy endpoint was the rate of treatment failure within the first 6 months after transplantation. Treatment failure was defined as the first episode of acute rejection (confirmed by biopsy), graft loss, or death. Compared with azathioprine and placebo, sirolimus tablets (sirolimus) 2 mg/d and 5 mg/d dose levels significantly reduced the incidence of treatment failure 6 months after transplantation.

The above is the effect of (sirolimus) on kidney transplantation provided by our medical companion travel overseas medical consulting service company. Patients must strictly follow the doctor's instructions and use the medicine rationally, so that the effect of the medicine can be maximized.