苯丁酸钠的不良反应多不多？使用时要注意什么

Sodium phenylbutyrate may be used as an adjunct to dietary protein restriction and essential amino acid supplementation in the long-term management of patients with urea cycle disorders. It is reported that when patients with urea cycle disorders are treated with sodium phenylbutyrate (Buphenyl) (combined with controlling dietary nitrogen intake), blood ammonia and glutamate levels can be reduced or even reach normal levels. Sodium phenylbutyrate (Buphenyl) has a significant therapeutic effect, but the use of this drug can also produce some adverse reactions, so patients should not blindly use this drug for treatment. Are there many adverse reactions? What should I pay attention to when using it?

Sodium phenylbutyrate adverse reactions

Adverse reactions of sodium phenylbutyrate include: amenorrhea, dysmenorrhea, hypoalbuminemia, metabolic acidosis, anemia, anorexia, hypophosphatemia, hypernatremia, hyperuricemia, hypokalemia, leukopenia, strong body odor, thrombocytopenia, etc. Because each patient's condition and tolerance to drugs are different, the number of side effects that patients will experience after receiving sodium phenylbutyrate (Buphenyl) treatment will also be different and cannot be generalized. If patients have serious side effects during treatment, they should not use other drugs without authorization. They should go to the hospital in time and seek help from professional doctors to avoid delaying the condition.

Precautions for sodium phenylbutyrate

Patients who are allergic to sodium phenylbutyrate (Buphenyl) or any excipients should not use this drug for treatment. If serious adverse reactions occur, the patient should go to the hospital immediately and seek professional help.

Hyperammonemia and hyperammonemic encephalopathy may occur with treatment with sodium phenylbutyrate (Buphenyl), and patients should treat hyperammonemia as a medical emergency.

Treatment with sodium phenylbutyrate (Buphenyl) may cause sodium and fluid retention. Patients with heart failure and patients with poor fluid retention should use this drug with caution. Patients with more serious conditions should seek help from a professional doctor, who will adjust the medication plan.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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