舒噻嗪(Ospolot)的功效与作用

Ospolot is a sulfonamide derivative anti-epileptic drug. The original research company is DesitinArzneimittel GmbH in Germany.

Effects and effects of Ospolot

1. Inhibiting carbonic anhydrase

is its most clear biological effect. Inhibiting this enzyme can affect the acid-base balance in the body, thereby reducing the excitability of neurons, thereby reducing epileptic seizures.

2. Stabilize the neuron membrane

It can reduce the entry of sodium ions into the interior of neurons, lower the excitation threshold of nerve cells, and make it less likely to produce abnormal discharges.

3. Regulate neurotransmitters

May regulate the balance of excitatory and inhibitory neurotransmitters in the brain.

Sutiazine can effectively inhibit epileptiform discharges and control epileptic seizures.

Ospolot indications

Treatment of continuous spike-and-wave syndrome (POCS) during sleep and should be considered only after failure of other available and appropriate treatment options.

It is a hospital-specific prescription drug and must be prescribed and supervised by a neurologist or pediatrician experienced in the field of epilepsy treatment.

The pictures come from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Usage and dosage of Ospolot

1. Instructions before use

Ospolot is available in two film-coated tablet forms: 50 mg and 200 mg (divisible).

2. How to take it

Swallow the whole tablet with water and do not chew it. It is recommended to take it with a large glass of water.

3. Dose determination

The dose needs to be determined based on the patient's weight and response. The usual maintenance dose range is 5 to 10 mg per kilogram of body weight per day.

Adopting a gradual increase in dose, especially gradually increasing it to the target maintenance dose within 1 to 2 weeks, can greatly reduce the occurrence of side effects. In some cases, your doctor may also decide to start treatment directly with a maintenance dose.

4. Dosing frequency

Dividing the total daily dose into three even doses can better maintain a stable blood drug concentration. Stable blood drug concentration usually takes 5 to 6 days to achieve.

5. Course of treatment

If no effect is observed after about one month of treatment, discontinuation of the drug should be considered.

Important precautions and warnings for Ospolot

1. Absolute contraindications

It is prohibited to be used by those who are allergic to Ospolot, other sulfa drugs or any ingredients in this product, patients with renal insufficiency, those with a history of mental illness, porphyria, hyperthyroidism and untreated hypertension.

2. Necessary monitoring

Long-term treatment requires regular monitoring of blood routine and renal function (before treatment, once a week in the first month, once a month thereafter, and 2-4 times a year after half a year).

In case of fever, sore throat, rash and other symptoms that may indicate a serious blood or skin reaction, you must seek medical treatment immediately and stop taking the drug.

3. Risk of metabolic acidosis

As a carbonic anhydrase inhibitor, it may cause metabolic acidosis (symptoms include rapid breathing, fatigue, loss of appetite), and you need to be alert to its long-term risks (such as kidney stones, osteoporosis, growth retardation in children).

4. Lactose content

Considering the particularity of Suthiazine, which contains lactose, patients with related hereditary intolerance should not take it.